Microbiome Labs Zenbiome COPE Probiotic Mood Support, 60 Capsules with B6, B12 & Saffron

Microbiome Labs Zenbiome COPE is a probiotic mood-support supplement formulated to support coping with occasional stress, featuring Bifidobacterium longum 1714 and 60 capsules.

• Includes vitamins B6 and B12 with saffron extract — ingredients selected to support brain and mood functions.
• Suitable for women, men, teens and children ages 8+ — made for a range of age groups.
• A four-week human trial of Bifidobacterium longum 1714 — found changes in perceived stress, memory performance, mental fatigue and brainwave activity.
• Designed around the gut-brain axis — connects gut microbiota with brain health support.
• Made for occasional stressors and mild mood changes — also intended to support low energy, occasional fatigue and sleeplessness.

Everyday stress can coincide with changes in mood, energy and sleep. Zenbiome COPE brings a psychobiotic probiotic together with B vitamins and saffron in a supplement designed to support brain health, mood and the ability to cope with occasional stress. Its approach centers on the gut-brain axis: communication between the gut microbiota and the brain.

How does Zenbiome COPE support the gut-brain axis?

Its psychobiotic strain is Bifidobacterium longum 1714, a commensal bacterium selected for its role in gut-brain-axis support. The vagus nerve provides a physical route for gut-brain communication; studies show that 80–90% of its fibers are linked to the gut. The strain acts by targeting the HPA axis to support healthy cortisol levels.

• Psychobiotic refers to commensal bacteria that play a role in the gut-brain axis and support brain health.
• The strain’s proposed pathway is the HPA axis.

What findings are associated with strain 1714?

In a four-week human trial, Bifidobacterium longum 1714 was associated with lower perceived stress, improved memory performance, less mental fatigue, positive support for brainwave activity and improved ability to handle occasional stress. These are findings from a study of the strain, not a guaranteed individual outcome.

• The trial period was four weeks.
• The measured areas included perceived stress and memory performance.

How do the added B vitamins and saffron fit?

Vitamin B6 acts as a cofactor in converting glutamate to GABA and 5-HTP to serotonin, processes connected with natural mood support. Vitamin B12 is included to help maintain calm moods and positive coping mechanisms, while saffron is used to support central nervous function and mood.

• The formula pairs the probiotic with B6, B12 and saffron extract.
• The product is intended for women and men as well as teens and children ages 8+.

Zenbiome COPE is suited to people seeking probiotic-based support for occasional stress, mild mood changes, low energy, occasional fatigue or occasional sleeplessness. Its 60-capsule format combines a gut-brain-axis-focused probiotic with B vitamins and saffron for that intended purpose.